Genome-Wide Analysis of Off-Target CRISPR/Cas9 Activity in Single-Cell-Derived Human Hematopoietic Stem and Progenitor Cell Clones

CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9)-mediated genome editing holds remarkable promise for the treatment of human genetic diseases. However, the possibility of off-target Cas9 activity remains a concern. To address this issue using clinic...

Descripción completa

Detalles Bibliográficos
Autores principales: Smith, Richard H., Chen, Yun-Ching, Seifuddin, Fayaz, Hupalo, Daniel, Alba, Camille, Reger, Robert, Tian, Xin, Araki, Daisuke, Dalgard, Clifton L., Childs, Richard W., Pirooznia, Mehdi, Larochelle, Andre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762975/
https://www.ncbi.nlm.nih.gov/pubmed/33322084
http://dx.doi.org/10.3390/genes11121501

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762975/
https://www.ncbi.nlm.nih.gov/pubmed/33322084
http://dx.doi.org/10.3390/genes11121501

Ejemplares similares