Molecular Diversity via Tetrasubstituted Alkenes Containing a Barbiturate Motif: Synthesis and Biological Activity

The synthesis of a molecularly diverse library of tetrasubstituted alkenes containing a barbiturate motif is described. Base-induced condensation of N(1)-substituted pyrimidine-2,4,6(1H,3H,5H)-triones with 5-(bis(methylthio)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione gave 3-substituted 5-(methylth...

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Detalles Bibliográficos
Autores principales: Al-Sheikh, Ahmed, Begum, Masuma, Zhang, Bian, Lewis, Richard A., Allenby, Nicholas E. E., Waddell, Paul G., Golding, Bernard T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763037/
https://www.ncbi.nlm.nih.gov/pubmed/33322563
http://dx.doi.org/10.3390/molecules25245868

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763037/
https://www.ncbi.nlm.nih.gov/pubmed/33322563
http://dx.doi.org/10.3390/molecules25245868

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