Differential Effects of IGF-1R Small Molecule Tyrosine Kinase Inhibitors BMS-754807 and OSI-906 on Human Cancer Cell Lines

SIMPLE SUMMARY: We have tested the effects of IGF-1R tyrosine kinase inhibitors BMS-754807 (BMS) and OSI-906 (OSI) on human colon, pancreatic carcinoma cell, and glioblastoma cell lines and primary cultures. Although OSI and BMS are able to inhibit IGF-1R activity at low doses, the differential effe...

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Detalles Bibliográficos
Autores principales: Fuentes-Baile, María, Ventero, María P., Encinar, José A., García-Morales, Pilar, Poveda-Deltell, María, Pérez-Valenciano, Elizabeth, Barberá, Víctor M., Gallego-Plazas, Javier, Rodríguez-Lescure, Álvaro, Martín-Nieto, José, Saceda, Miguel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763458/
https://www.ncbi.nlm.nih.gov/pubmed/33322337
http://dx.doi.org/10.3390/cancers12123717

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763458/
https://www.ncbi.nlm.nih.gov/pubmed/33322337
http://dx.doi.org/10.3390/cancers12123717

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