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Enzymatic Hydroxylation and Excision of Extended 5-Methylcytosine Analogues
Methylation of cytosine to 5-methylcytosine (mC) is a prevalent reversible epigenetic mark in vertebrates established by DNA methyltransferases (MTases); the methylation mark can be actively erased via a multi-step demethylation mechanism involving oxidation by Ten-eleven translocation (TET) enzyme...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763475/ https://www.ncbi.nlm.nih.gov/pubmed/33065111 http://dx.doi.org/10.1016/j.jmb.2020.10.011 |