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Glycosaminoglycan Modification of Decorin Depends on MMP14 Activity and Regulates Collagen Assembly

Proper processing of collagens COL1 and COL6 is required for normal function of adipose tissue and skeletal muscle. Proteoglycan decorin (DCN) regulates collagen fiber formation. The amino-terminus of DCN is modified with an O-linked glycosaminoglycan (GAG), the function of which has remained unclea...

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Detalles Bibliográficos
Autores principales: Daquinag, Alexes C., Gao, Zhanguo, Fussell, Cale, Sun, Kai, Kolonin, Mikhail G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764107/
https://www.ncbi.nlm.nih.gov/pubmed/33317052
http://dx.doi.org/10.3390/cells9122646