Cargando…

Dysregulated Interferon Response Underlying Severe COVID-19

Innate immune interferons (IFNs), including type I and III IFNs, constitute critical antiviral mechanisms. Recent studies reveal that IFN dysregulation is key to determine COVID-19 pathogenesis. Effective IFN stimulation or prophylactic administration of IFNs at the early stage prior to severe COVID...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lopez, LeAnn, Sang, Peter C., Tian, Yun, Sang, Yongming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764122/ https://www.ncbi.nlm.nih.gov/pubmed/33322160 http://dx.doi.org/10.3390/v12121433

Ejemplares similares

Immunogenetic Association Underlying Severe COVID-19
por: McCoy, Kendall, et al.
Publicado: (2020)

Viral Infections and Interferons in the Development of Obesity
por: Tian, Yun, et al.
Publicado: (2019)

Immunometabolic Dysregulation at the Intersection of Obesity and COVID-19
por: Khwatenge, Collins N., et al.
Publicado: (2021)

Dysregulation of type I interferon responses in COVID-19
por: Acharya, Dhiraj, et al.
Publicado: (2020)

Epigenetic Evolution of ACE2 and IL-6 Genes: Non-Canonical Interferon-Stimulated Genes Correlate to COVID-19 Susceptibility in Vertebrates
por: Sang, Eric R., et al.
Publicado: (2021)

Xenopus Interferon Complex: Inscribing the Amphibiotic Adaption and Species-Specific Pathogenic Pressure in Vertebrate Evolution?
por: Tian, Yun, et al.
Publicado: (2019)

Dysregulated early transcriptional signatures linked to mast cell and interferon responses are implicated in COVID-19 severity
por: MacCann, Rachel, et al.
Publicado: (2023)

Dysregulated Interferon Response and Immune Hyperactivation in Severe COVID-19: Targeting STATs as a Novel Therapeutic Strategy
por: Eskandarian Boroujeni, Mahdi, et al.
Publicado: (2022)

Porcine Interferon Complex and Co-Evolution with Increasing Viral Pressure after Domestication
por: Jennings, Jordan, et al.
Publicado: (2019)

Dysregulation of Pulmonary Responses in Severe COVID-19
por: Wu, Dandan, et al.
Publicado: (2021)

Comparative transcriptomics reveals small RNA composition and differential microRNA responses underlying interferon-mediated antiviral regulation in porcine alveolar macrophages
por: Li, Jiuyi, et al.
Publicado: (2022)

Hyperlipidemia and Obesity’s Role in Immune Dysregulation Underlying the Severity of COVID-19 Infection
por: Khatchadourian, Christopher, et al.
Publicado: (2021)

Integrate structural analysis, isoform diversity, and interferon-inductive propensity of ACE2 to predict SARS-CoV2 susceptibility in vertebrates
por: Sang, Eric R., et al.
Publicado: (2020)

Interferon-Driven Immune Dysregulation in Down Syndrome: A Review of the Evidence
por: Chung, Howard, et al.
Publicado: (2021)

Dysregulated adaptive immune response contributes to severe COVID-19
por: Yu, Kuai, et al.
Publicado: (2020)

Virus-Targeted Transcriptomic Analyses Implicate Ranaviral Interaction with Host Interferon Response in Frog Virus 3-Infected Frog Tissues
por: Tian, Yun, et al.
Publicado: (2021)

The role of dysregulated immune responses in COVID-19 pathogenesis
por: Tahaghoghi-Hajghorbani, S, et al.
Publicado: (2020)

Sleep Assessments for Children With Severe Cerebral Palsy: A Scoping Review
por: Hutson, Jennifer A., et al.
Publicado: (2020)

Hallmarks of immune response in COVID-19: Exploring dysregulation and exhaustion
por: Mazzoni, Alessio, et al.
Publicado: (2021)

Epigenetic dysregulation of ACE2 and interferon-regulated genes might suggest increased COVID-19 susceptibility and severity in lupus patients
por: Sawalha, Amr H., et al.
Publicado: (2020)

Expansion of amphibian intronless interferons revises the paradigm for interferon evolution and functional diversity
por: Sang, Yongming, et al.
Publicado: (2016)

Porcine type I interferons: polymorphic sequences and activity against PRRSV
por: Sang, Yongming, et al.
Publicado: (2011)

Dysregulated inflammation may predispose patients with serious mental illnesses to severe COVID-19
por: Nadalin, Sergej, et al.
Publicado: (2021)

Immune dysregulation and system pathology in COVID-19
por: Jamal, Muhammad, et al.
Publicado: (2021)

Obesity and Leptin Resistance in the Regulation of the Type I Interferon Early Response and the Increased Risk for Severe COVID-19
por: Muskiet, Frits A. J., et al.
Publicado: (2022)

Dysregulation of immunity in COVID-19 and SLE
por: Hejazian, Seyyed Sina, et al.
Publicado: (2022)

Severe COVID-19: NLRP3 Inflammasome Dysregulated
por: van den Berg, Daan F., et al.
Publicado: (2020)

Complement dysregulation is associated with severe COVID-19 illness
por: Yu, Jia, et al.
Publicado: (2021)

Dysregulated Immune Responses in COVID-19 Patients Correlating With Disease Severity and Invasive Oxygen Requirements
por: García-González, Paulina, et al.
Publicado: (2021)

Correlation between Type I Interferon Associated Factors and COVID-19 Severity
por: Bencze, Dóra, et al.
Publicado: (2022)

Molecular Evolution of the Porcine Type I Interferon Family: Subtype-Specific Expression and Antiviral Activity
por: Sang, Yongming, et al.
Publicado: (2014)

Impaired interferon signature in severe COVID-19
por: Gruber, Conor
Publicado: (2020)

Endoplasmic reticulum stress and autophagy dysregulation in alcoholic and non-alcoholic liver diseases
por: Kim, Yun Seok, et al.
Publicado: (2020)

The Ebola Interferon Inhibiting Domains Attenuate and Dysregulate Cell-Mediated Immune Responses
por: Lubaki, Ndongala Michel, et al.
Publicado: (2016)

Dysregulated Liver Metabolism and Polycystic Ovarian Syndrome
por: Khan, Muhammad Sohaib, et al.
Publicado: (2023)

Dysregulated Calcium Handling in Cirrhotic Cardiomyopathy
por: Hwang, Sang Youn, et al.
Publicado: (2023)

Type I interferon: From innate response to treatment for COVID‐19
por: Lin, Fuyu, et al.
Publicado: (2020)

Sepsis, complement and the dysregulated inflammatory response
por: Ward, Peter A, et al.
Publicado: (2009)

Myeloid dysregulation and therapeutic intervention in COVID-19
por: Gu, Runxia, et al.
Publicado: (2021)

Cell type-specific immune dysregulation in severely ill COVID-19 patients
por: Yao, Changfu, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_c8edu9lulu57er1pq69if2ic3k