Cargando…

The Failed Clinical Story of Myostatin Inhibitors against Duchenne Muscular Dystrophy: Exploring the Biology behind the Battle

Myostatin inhibition therapy has held much promise for the treatment of muscle wasting disorders. This is particularly true for the fatal myopathy, Duchenne Muscular Dystrophy (DMD). Following on from promising pre-clinical data in dystrophin-deficient mice and dogs, several clinical trials were ini...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rybalka, Emma, Timpani, Cara A., Debruin, Danielle A., Bagaric, Ryan M., Campelj, Dean G., Hayes, Alan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Perspective
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764137/ https://www.ncbi.nlm.nih.gov/pubmed/33322031 http://dx.doi.org/10.3390/cells9122657

Ejemplares similares

The Effect of Vitamin D Supplementation on Skeletal Muscle in the mdx Mouse Model of Duchenne Muscular Dystrophy
por: Debruin, Danielle A., et al.
Publicado: (2019)

Standard of care versus new-wave corticosteroids in the treatment of Duchenne muscular dystrophy: Can we do better?
por: Kourakis, Stephanie, et al.
Publicado: (2021)

Nitric Oxide (NO) and Duchenne Muscular Dystrophy: NO Way to Go?
por: Timpani, Cara A., et al.
Publicado: (2020)

Therapeutic strategies to address neuronal nitric oxide synthase deficiency and the loss of nitric oxide bioavailability in Duchenne Muscular Dystrophy
por: Timpani, Cara A., et al.
Publicado: (2017)

Targeting Nrf2 for the treatment of Duchenne Muscular Dystrophy
por: Kourakis, Stephanie, et al.
Publicado: (2020)

Metabogenic and Nutriceutical Approaches to Address Energy Dysregulation and Skeletal Muscle Wasting in Duchenne Muscular Dystrophy
por: Rybalka, Emma, et al.
Publicado: (2015)

Adenylosuccinic acid therapy ameliorates murine Duchenne Muscular Dystrophy
por: Timpani, Cara A., et al.
Publicado: (2020)

Sodium nitrate co-supplementation does not exacerbate low dose metronomic doxorubicin-induced cachexia in healthy mice
por: Campelj, Dean G., et al.
Publicado: (2020)

Cachectic muscle wasting in acute myeloid leukaemia: a sleeping giant with dire clinical consequences
por: Campelj, Dean G., et al.
Publicado: (2021)

Dual exon skipping in myostatin and dystrophin for Duchenne muscular dystrophy
por: Kemaladewi, Dwi U, et al.
Publicado: (2011)

Myostatin Is a Quantifiable Biomarker for Monitoring Pharmaco-gene Therapy in Duchenne Muscular Dystrophy
por: Mariot, Virginie, et al.
Publicado: (2020)

The Paradoxical Effect of PARP Inhibitor BGP-15 on Irinotecan-Induced Cachexia and Skeletal Muscle Dysfunction
por: Campelj, Dean G., et al.
Publicado: (2020)

Exercise May Ameliorate the Detrimental Side Effects of High Vitamin D Supplementation on Muscle Function in Mice
por: Debruin, Danielle A, et al.
Publicado: (2020)

Two novel missense mutations in the myostatin gene identified in Japanese patients with Duchenne muscular dystrophy
por: Nishiyama, Atsushi, et al.
Publicado: (2007)

Asynchronous remodeling is a driver of failed regeneration in Duchenne muscular dystrophy
por: Dadgar, Sherry, et al.
Publicado: (2014)

Metronomic 5-Fluorouracil Delivery Primes Skeletal Muscle for Myopathy but Does Not Cause Cachexia
por: Campelj, Dean G., et al.
Publicado: (2021)

Survival in Duchenne muscular dystrophy
por: RALL, SUSANNE, et al.
Publicado: (2012)

Theragnosis for Duchenne Muscular Dystrophy
por: Luce, Leonela, et al.
Publicado: (2021)

Disrupted Calcium Homeostasis in Duchenne Muscular Dystrophy: A Common Mechanism behind Diverse Consequences
por: Zabłocka, Barbara, et al.
Publicado: (2021)

Diminution in sperm quantity and quality in mouse models of Duchenne Muscular Dystrophy induced by a myostatin-based muscle growth-promoting intervention
por: Vaughan, Danielle, et al.
Publicado: (2020)

Hypokalemia complicating Duchenne muscular dystrophy.
por: McDonald, B., et al.
Publicado: (1987)

The role of fibrosis in Duchenne muscular dystrophy
por: KLINGLER, WERNER, et al.
Publicado: (2012)

Delay in Diagnosis of Duchenne Muscular Dystrophy
por: Rao, Vamshi K., et al.
Publicado: (2015)

Circulating Biomarkers for Duchenne Muscular Dystrophy
por: Aartsma-Rus, Annemieke, et al.
Publicado: (2015)

Targeting angiogenesis in Duchenne muscular dystrophy
por: Podkalicka, Paulina, et al.
Publicado: (2019)

Regenerative biomarkers for Duchenne muscular dystrophy
por: Guiraud, Simon, et al.
Publicado: (2019)

Eteplirsen in the treatment of Duchenne muscular dystrophy
por: Lim, Kenji Rowel Q, et al.
Publicado: (2017)

Nutritional Challenges in Duchenne Muscular Dystrophy
por: Salera, Simona, et al.
Publicado: (2017)

Lifetime Care of Duchenne Muscular Dystrophy
por: MacKintosh, Erin W., et al.
Publicado: (2020)

The Duchenne muscular dystrophy gene and cancer
por: Jones, Leanne, et al.
Publicado: (2020)

CRISPR Therapeutics for Duchenne Muscular Dystrophy
por: Erkut, Esra, et al.
Publicado: (2022)

Exon-Skipping in Duchenne Muscular Dystrophy
por: Takeda, Shin’ichi, et al.
Publicado: (2021)

Gene Therapy for Duchenne Muscular Dystrophy
por: Elangkovan, Nertiyan, et al.
Publicado: (2021)

Family reflections: Duchenne Muscular Dystrophy
por: Gill, Omaira
Publicado: (2022)

Cardiac therapies for Duchenne muscular dystrophy
por: Shah, Md Nur Ahad, et al.
Publicado: (2023)

Newborn screening for Duchenne muscular dystrophy‐early detection and diagnostic algorithm for female carriers of Duchenne muscular dystrophy
por: Gruber, Dorota, et al.
Publicado: (2022)

BGP-15 Protects against Oxaliplatin-Induced Skeletal Myopathy and Mitochondrial Reactive Oxygen Species Production in Mice
por: Sorensen, James C., et al.
Publicado: (2017)

Effect of Yoga and Ayurveda on Duchenne Muscular Dystrophy
por: Telles, Shirley, et al.
Publicado: (2011)

Symptomatic therapy of Duchenne Muscular Dystrophy (DMD)
por: Rüdel, Reinhardt
Publicado: (2012)

Presence of mechanical dyssynchrony in duchenne muscular dystrophy
por: Hor, Kan N, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_upqcjeddqebaissfqc4knc4j2j