Mechanisms of EMRE-Dependent MCU Opening in the Mitochondrial Calcium Uniporter Complex

The mitochondrial calcium uniporter is a multi-subunit Ca(2+)-activated Ca(2+) channel, made up of the pore-forming MCU protein, a metazoan-specific EMRE subunit, and MICU1/MICU2, which mediate Ca(2+) activation. It has been established that metazoan MCU requires EMRE binding to conduct Ca(2+), but...

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Detalles Bibliográficos
Autores principales: Van Keuren, Anna M., Tsai, Chen-Wei, Balderas, Enrique, Rodriguez, Madison X., Chaudhuri, Dipayan, Tsai, Ming-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764451/
https://www.ncbi.nlm.nih.gov/pubmed/33296646
http://dx.doi.org/10.1016/j.celrep.2020.108486

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764451/
https://www.ncbi.nlm.nih.gov/pubmed/33296646
http://dx.doi.org/10.1016/j.celrep.2020.108486

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