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Mechanisms of EMRE-Dependent MCU Opening in the Mitochondrial Calcium Uniporter Complex

The mitochondrial calcium uniporter is a multi-subunit Ca(2+)-activated Ca(2+) channel, made up of the pore-forming MCU protein, a metazoan-specific EMRE subunit, and MICU1/MICU2, which mediate Ca(2+) activation. It has been established that metazoan MCU requires EMRE binding to conduct Ca(2+), but...

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Detalles Bibliográficos
Autores principales:	Van Keuren, Anna M., Tsai, Chen-Wei, Balderas, Enrique, Rodriguez, Madison X., Chaudhuri, Dipayan, Tsai, Ming-Feng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764451/ https://www.ncbi.nlm.nih.gov/pubmed/33296646 http://dx.doi.org/10.1016/j.celrep.2020.108486

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