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Changes in Ion Selectivity Following the Asymmetrical Addition of Charge to the Selectivity Filter of Bacterial Sodium Channels

Voltage-gated sodium channels (NaVs) play fundamental roles in eukaryotes, but their exceptional size hinders their structural resolution. Bacterial NaVs are simplified homologues of their eukaryotic counterparts, but their use as models of eukaryotic Na(+) channels is limited by their homotetrameri...

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Detalles Bibliográficos
Autores principales: Fedorenko, Olena A., Khovanov, Igor A., Roberts, Stephen K., Guardiani, Carlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764494/
https://www.ncbi.nlm.nih.gov/pubmed/33316962
http://dx.doi.org/10.3390/e22121390