Vascular dysfunction promotes regional hypoxia after bevacizumab therapy in recurrent glioblastoma patients

BACKGROUND: Hypoxia is a driver of treatment resistance in glioblastoma. Antiangiogenic agents may transiently normalize blood vessels and decrease hypoxia before excessive pruning of vessels increases hypoxia. The time window of normalization is dose and time dependent. We sought to determine how V...

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Detalles Bibliográficos
Autores principales: Gerstner, Elizabeth R, Emblem, Kyrre E, Yen, Yi-Fen, Dietrich, Jorg, Jordan, Justin T, Catana, Ciprian, Wenchin, Kevin Lou, Hooker, Jacob M, Duda, Dan G, Rosen, Bruce R, Kalpathy-Cramer, Jayashree, Jain, Rakesh K, Batchelor, Tracy T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Clinical Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764510/
https://www.ncbi.nlm.nih.gov/pubmed/33392506
http://dx.doi.org/10.1093/noajnl/vdaa157

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764510/
https://www.ncbi.nlm.nih.gov/pubmed/33392506
http://dx.doi.org/10.1093/noajnl/vdaa157

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