Novel Small Molecular Compound AE-848 Potently Induces Human Multiple Myeloma Cell Apoptosis by Modulating the NF-κB and PI3K/Akt/mTOR Signaling Pathways

BACKGROUND: We aimed to investigate the anti-multiple myeloma (MM) activity of the new small molecular compound AE-848 (5-bromo-2-hydroxyisophthalaldehyde bis[(1-methyl-1H-benzimidazol-2-yl)hydrazone]) and its underlying anti-MM mechanism. METHODS: Cell viability and apoptosis were detected and quan...

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Detalles Bibliográficos
Autores principales: Xu, Yaqi, Feng, Xiaoli, Zhou, Qian, Jiang, Wen, Dai, Yibo, Jiang, Yang, Liu, Xiaoli, Li, Shuo, Wang, Yongjing, Wang, Fang, Li, Ai, Zheng, Chengyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764792/
https://www.ncbi.nlm.nih.gov/pubmed/33376355
http://dx.doi.org/10.2147/OTT.S270090

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764792/
https://www.ncbi.nlm.nih.gov/pubmed/33376355
http://dx.doi.org/10.2147/OTT.S270090

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