HNC0014, a Multi-Targeted Small-Molecule, Inhibits Head and Neck Squamous Cell Carcinoma by Suppressing c-Met/STAT3/CD44/PD-L1 Oncoimmune Signature and Eliciting Antitumor Immune Responses

SIMPLE SUMMARY: Cancer stem cells (CSCs) in head and neck squamous cell carcinoma (HNSCC) possess unlimited self-renewal capacity, resist treatments and induce tumor repopulation after interventions. Here, we observed HNSCC CSCs secreted exosomes containing c-Met, STAT3 (also the phosphorylated form...

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Detalles Bibliográficos
Autores principales: Lee, Jih-Chin, Wu, Alexander T.H., Chen, Jia-Hong, Huang, Wen-Yen, Lawal, Bashir, Mokgautsi, Ntlotlang, Huang, Hsu-Shan, Ho, Ching-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764918/
https://www.ncbi.nlm.nih.gov/pubmed/33327484
http://dx.doi.org/10.3390/cancers12123759

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7764918/
https://www.ncbi.nlm.nih.gov/pubmed/33327484
http://dx.doi.org/10.3390/cancers12123759

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