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A quantitative analysis of the interplay of environment, neighborhood, and cell state in 3D spheroids

Cells react to their microenvironment by integrating external stimuli into phenotypic decisions via an intracellular signaling network. To analyze the interplay of environment, local neighborhood, and internal cell state effects on phenotypic variability, we developed an experimental approach that e...

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Detalles Bibliográficos
Autores principales: Zanotelli, Vito RT, Leutenegger, Matthias, Lun, Xiao‐Kang, Georgi, Fanny, de Souza, Natalie, Bodenmiller, Bernd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765047/
https://www.ncbi.nlm.nih.gov/pubmed/33369114
http://dx.doi.org/10.15252/msb.20209798