Acute Conditioning of Antigen-Expanded CD8(+) T Cells via the GSK3β-mTORC Axis Differentially Dictates Their Immediate and Distal Responses after Antigen Rechallenge

SIMPLE SUMMARY: Expanded, antigen-experienced CD8(+) T cells are utilized in immunotherapy to treat infections and cancers. Antigen rechallenge of these cells leads to their re-expansion. The effector functions of re-expanded CD8(+) T cells are critical for their therapeutic efficacy. We found that...

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Detalles Bibliográficos
Autores principales: Taborska, Pavla, Stakheev, Dmitry, Svobodova, Hana, Strizova, Zuzana, Bartunkova, Jirina, Smrz, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765077/
https://www.ncbi.nlm.nih.gov/pubmed/33327544
http://dx.doi.org/10.3390/cancers12123766

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765077/
https://www.ncbi.nlm.nih.gov/pubmed/33327544
http://dx.doi.org/10.3390/cancers12123766

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