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Acute Conditioning of Antigen-Expanded CD8(+) T Cells via the GSK3β-mTORC Axis Differentially Dictates Their Immediate and Distal Responses after Antigen Rechallenge
SIMPLE SUMMARY: Expanded, antigen-experienced CD8(+) T cells are utilized in immunotherapy to treat infections and cancers. Antigen rechallenge of these cells leads to their re-expansion. The effector functions of re-expanded CD8(+) T cells are critical for their therapeutic efficacy. We found that...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765077/ https://www.ncbi.nlm.nih.gov/pubmed/33327544 http://dx.doi.org/10.3390/cancers12123766 |