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Mechanisms Underlying the Skin-Gut Cross Talk in the Development of IgE-Mediated Food Allergy

Immune-globulin E (IgE)-mediated food allergy is characterized by a variety of clinical entities within the gastrointestinal tract, skin and lungs, and systemically as anaphylaxis. The default response to food antigens, which is antigen specific immune tolerance, requires exposure to the antigen and...

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Autores principales: van Splunter, Marloes, Liu, Liu, van Neerven, R.J. Joost, Wichers, Harry J., Hettinga, Kasper A., de Jong, Nicolette W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765270/
https://www.ncbi.nlm.nih.gov/pubmed/33333859
http://dx.doi.org/10.3390/nu12123830
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author van Splunter, Marloes
Liu, Liu
van Neerven, R.J. Joost
Wichers, Harry J.
Hettinga, Kasper A.
de Jong, Nicolette W.
author_facet van Splunter, Marloes
Liu, Liu
van Neerven, R.J. Joost
Wichers, Harry J.
Hettinga, Kasper A.
de Jong, Nicolette W.
author_sort van Splunter, Marloes
collection PubMed
description Immune-globulin E (IgE)-mediated food allergy is characterized by a variety of clinical entities within the gastrointestinal tract, skin and lungs, and systemically as anaphylaxis. The default response to food antigens, which is antigen specific immune tolerance, requires exposure to the antigen and is already initiated during pregnancy. After birth, tolerance is mostly acquired in the gut after oral ingestion of dietary proteins, whilst exposure to these same proteins via the skin, especially when it is inflamed and has a disrupted barrier, can lead to allergic sensitization. The crosstalk between the skin and the gut, which is involved in the induction of food allergy, is still incompletely understood. In this review, we will focus on mechanisms underlying allergic sensitization (to food antigens) via the skin, leading to gastrointestinal inflammation, and the development of IgE-mediated food allergy. Better understanding of these processes will eventually help to develop new preventive and therapeutic strategies in children.
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spelling pubmed-77652702020-12-27 Mechanisms Underlying the Skin-Gut Cross Talk in the Development of IgE-Mediated Food Allergy van Splunter, Marloes Liu, Liu van Neerven, R.J. Joost Wichers, Harry J. Hettinga, Kasper A. de Jong, Nicolette W. Nutrients Review Immune-globulin E (IgE)-mediated food allergy is characterized by a variety of clinical entities within the gastrointestinal tract, skin and lungs, and systemically as anaphylaxis. The default response to food antigens, which is antigen specific immune tolerance, requires exposure to the antigen and is already initiated during pregnancy. After birth, tolerance is mostly acquired in the gut after oral ingestion of dietary proteins, whilst exposure to these same proteins via the skin, especially when it is inflamed and has a disrupted barrier, can lead to allergic sensitization. The crosstalk between the skin and the gut, which is involved in the induction of food allergy, is still incompletely understood. In this review, we will focus on mechanisms underlying allergic sensitization (to food antigens) via the skin, leading to gastrointestinal inflammation, and the development of IgE-mediated food allergy. Better understanding of these processes will eventually help to develop new preventive and therapeutic strategies in children. MDPI 2020-12-15 /pmc/articles/PMC7765270/ /pubmed/33333859 http://dx.doi.org/10.3390/nu12123830 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
van Splunter, Marloes
Liu, Liu
van Neerven, R.J. Joost
Wichers, Harry J.
Hettinga, Kasper A.
de Jong, Nicolette W.
Mechanisms Underlying the Skin-Gut Cross Talk in the Development of IgE-Mediated Food Allergy
title Mechanisms Underlying the Skin-Gut Cross Talk in the Development of IgE-Mediated Food Allergy
title_full Mechanisms Underlying the Skin-Gut Cross Talk in the Development of IgE-Mediated Food Allergy
title_fullStr Mechanisms Underlying the Skin-Gut Cross Talk in the Development of IgE-Mediated Food Allergy
title_full_unstemmed Mechanisms Underlying the Skin-Gut Cross Talk in the Development of IgE-Mediated Food Allergy
title_short Mechanisms Underlying the Skin-Gut Cross Talk in the Development of IgE-Mediated Food Allergy
title_sort mechanisms underlying the skin-gut cross talk in the development of ige-mediated food allergy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765270/
https://www.ncbi.nlm.nih.gov/pubmed/33333859
http://dx.doi.org/10.3390/nu12123830
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