Mechanisms Generating Cancer Genome Complexity: Back to the Future

SIMPLE SUMMARY: In the 1990s, fluorescent in situ hybridization approaches made it possible to analyze the early stages of gene amplification in mammalian cells. These studies established breakage-fusion-bridge cycles as a major mechanism of intrachromosomal gene amplification. They also revealed th...

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Detalles Bibliográficos
Autor principal: Toledo, Franck
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765419/
https://www.ncbi.nlm.nih.gov/pubmed/33334014
http://dx.doi.org/10.3390/cancers12123783

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765419/
https://www.ncbi.nlm.nih.gov/pubmed/33334014
http://dx.doi.org/10.3390/cancers12123783

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