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Mechanisms Generating Cancer Genome Complexity: Back to the Future
SIMPLE SUMMARY: In the 1990s, fluorescent in situ hybridization approaches made it possible to analyze the early stages of gene amplification in mammalian cells. These studies established breakage-fusion-bridge cycles as a major mechanism of intrachromosomal gene amplification. They also revealed th...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765419/ https://www.ncbi.nlm.nih.gov/pubmed/33334014 http://dx.doi.org/10.3390/cancers12123783 |