In Silico/In Vitro Hit-to-Lead Methodology Yields SMYD3 Inhibitor That Eliminates Unrestrained Proliferation of Breast Carcinoma Cells

SMYD3 is a lysine methyltransferase that regulates the expression of over 80 genes and is required for the uncontrolled proliferation of most breast, colorectal, and hepatocellular carcinomas. The elimination of SMYD3 restores normal expression patterns of these genes and halts aberrant cell prolife...

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Detalles Bibliográficos
Autores principales: Alshiraihi, Ilham M., Jarrell, Dillon K., Arhouma, Zeyad, Hassell, Kelly N., Montgomery, Jaelyn, Padilla, Alyssa, Ibrahim, Hend M., Crans, Debbie C., Kato, Takamitsu A., Brown, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765450/
https://www.ncbi.nlm.nih.gov/pubmed/33333978
http://dx.doi.org/10.3390/ijms21249549

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765450/
https://www.ncbi.nlm.nih.gov/pubmed/33333978
http://dx.doi.org/10.3390/ijms21249549

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