APC Mutations Are Not Confined to Hotspot Regions in Early-Onset Colorectal Cancer

SIMPLE SUMMARY: Mutation of the APC gene is a common early event in colorectal cancer, however lower rates have been reported in younger cohorts of colorectal cancer patients. In sporadic cancer, mutations are typically clustered around a mutation cluster region, a narrowly defined hotspot within th...

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Detalles Bibliográficos
Autores principales: Aitchison, Alan, Hakkaart, Christopher, Day, Robert C., Morrin, Helen R., Frizelle, Frank A., Keenan, Jacqueline I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766084/
https://www.ncbi.nlm.nih.gov/pubmed/33352971
http://dx.doi.org/10.3390/cancers12123829

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766084/
https://www.ncbi.nlm.nih.gov/pubmed/33352971
http://dx.doi.org/10.3390/cancers12123829

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