Cargando…

NAMPT Over-Expression Recapitulates the BRAF Inhibitor Resistant Phenotype Plasticity in Melanoma

SIMPLE SUMMARY: Malignant melanoma (MM) is the most fatal skin cancer due to its high metastatic potential. Treatment strategies are dramatically changing due to the introduction of BRAF/MEK inhibitors (i) and immunotherapy; however, multiple resistant mechanisms rapidly occur including metabolic re...

Descripción completa

Detalles Bibliográficos
Autores principales:	Audrito, Valentina, Messana, Vincenzo Gianluca, Moiso, Enrico, Vitale, Nicoletta, Arruga, Francesca, Brandimarte, Lorenzo, Gaudino, Federica, Pellegrino, Elisa, Vaisitti, Tiziana, Riganti, Chiara, Piva, Roberto, Deaglio, Silvia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766175/ https://www.ncbi.nlm.nih.gov/pubmed/33419372 http://dx.doi.org/10.3390/cancers12123855

Ejemplares similares

Tumors carrying BRAF-mutations over-express NAMPT that is genetically amplified and possesses oncogenic properties
por: Audrito, Valentina, et al.
Publicado: (2022)

NAMPT and NAPRT: Two Metabolic Enzymes With Key Roles in Inflammation
por: Audrito, Valentina, et al.
Publicado: (2020)

The Extracellular NADome Modulates Immune Responses
por: Audrito, Valentina, et al.
Publicado: (2021)

Extracellular nicotinamide phosphoribosyltransferase (eNAMPT) is a novel marker for patients with BRAF-mutated metastatic melanoma
por: Audrito, Valentina, et al.
Publicado: (2018)

Immune Response Dysfunction in Chronic Lymphocytic Leukemia: Dissecting Molecular Mechanisms and Microenvironmental Conditions
por: Arruga, Francesca, et al.
Publicado: (2020)

Targeting the Adenosinergic Axis in Chronic Lymphocytic Leukemia: A Way to Disrupt the Tumor Niche?
por: Vaisitti, Tiziana, et al.
Publicado: (2018)

The NOTCH Pathway and Its Mutations in Mature B Cell Malignancies
por: Arruga, Francesca, et al.
Publicado: (2018)

Ectonucleotidases in Blood Malignancies: A Tale of Surface Markers and Therapeutic Targets
por: Vaisitti, Tiziana, et al.
Publicado: (2019)

NAD-Biosynthetic and Consuming Enzymes as Central Players of Metabolic Regulation of Innate and Adaptive Immune Responses in Cancer
por: Audrito, Valentina, et al.
Publicado: (2019)

Targeting metabolism and survival in chronic lymphocytic leukemia and Richter syndrome cells by a novel NF-κB inhibitor
por: Vaisitti, Tiziana, et al.
Publicado: (2017)

Targeting the A2A adenosine receptor counteracts immunosuppression in vivo in a mouse model of chronic lymphocytic leukemia
por: Arruga, Francesca, et al.
Publicado: (2020)

Anti-tumor activity of selinexor in combination with antineoplastic agents in chronic lymphocytic leukemia
por: Vitale, Candida, et al.
Publicado: (2023)

The dual face of NAMPT: Intracellular/extracellular protein and diagnostic/therapeutic target in cancer
por: Audrito, Valentina
Publicado: (2020)

Anti-CD37 α-amanitin–conjugated antibodies as potential therapeutic weapons for Richter syndrome
por: Vaisitti, Tiziana, et al.
Publicado: (2022)

Chronic Lymphocytic Leukemia
por: Vaisitti, Tiziana, et al.
Publicado: (2020)

Novel Approaches for the Treatment of Patients with Richter’s Syndrome
por: Iannello, Andrea, et al.
Publicado: (2022)

NAD/NAMPT and mTOR Pathways in Melanoma: Drivers of Drug Resistance and Prospective Therapeutic Targets
por: Indini, Alice, et al.
Publicado: (2022)

CA1 Nampt knockdown recapitulates hippocampal cognitive phenotypes in old mice which nicotinamide mononucleotide improves
por: Johnson, Sean, et al.
Publicado: (2018)

PD-L1 up-regulation in melanoma increases disease aggressiveness and is mediated through miR-17-5p
por: Audrito, Valentina, et al.
Publicado: (2017)

Linkage of NAMPT promoter variants to eNAMPT secretion, plasma eNAMPT levels, and ARDS severity
por: Lynn, Heather, et al.
Publicado: (2023)

Antagonists of growth hormone-releasing hormone (GHRH) inhibit the growth of human malignant pleural mesothelioma
por: Villanova, Tania, et al.
Publicado: (2019)

The immunomodulatory molecule TIGIT is expressed by chronic lymphocytic leukemia cells and contributes to anergy
por: Arruga, Francesca, et al.
Publicado: (2023)

Extracellular nicotinate phosphoribosyltransferase binds Toll like receptor 4 and mediates inflammation
por: Managò, Antonella, et al.
Publicado: (2019)

NAMPT-mediated NAD(+) biosynthesis is indispensable for adipose tissue plasticity and development of obesity
por: Nielsen, Karen Nørgaard, et al.
Publicado: (2018)

Cancer cell metabolic plasticity allows resistance to NAMPT inhibition but invariably induces dependence on LDHA
por: Thongon, Natthakan, et al.
Publicado: (2018)

PERK induces resistance to cell death elicited by endoplasmic reticulum stress and chemotherapy
por: Salaroglio, Iris C., et al.
Publicado: (2017)

Expression and Regulation of Nampt in Human Islets
por: Kover, Karen, et al.
Publicado: (2013)

Regulation of Regenerative Periodontal Healing by NAMPT
por: Nokhbehsaim, Marjan, et al.
Publicado: (2013)

Visfatin/Nampt: An Adipokine with Cardiovascular Impact
por: Romacho, Tania, et al.
Publicado: (2013)

Association of Nicotinamide Phosphoribosyltransferase (NAMPT) Gene Polymorphisms and of Serum NAMPT Levels with Dilated Cardiomyopathy in a Chinese Population
por: Dou, Qingyu, et al.
Publicado: (2015)

Endothelial eNAMPT drives EndMT and preclinical PH: rescue by an eNAMPT-neutralizing mAb
por: Ahmed, Mohamed, et al.
Publicado: (2021)

Chemistry-led investigations into the mode of action of NAMPT activators, resulting in the discovery of non-pyridyl class NAMPT activators
por: Tang, Siyuan, et al.
Publicado: (2023)

Macitentan, a double antagonist of endothelin receptors, efficiently impairs migration and microenvironmental survival signals in chronic lymphocytic leukemia
por: Maffei, Rossana, et al.
Publicado: (2017)

Validation of a Simple, Rapid, and Cost-Effective Method for Acute Rejection Monitoring in Lung Transplant Recipients
por: Sorbini, Monica, et al.
Publicado: (2022)

Role Played by Signalling Pathways in Overcoming BRAF Inhibitor Resistance in Melanoma
por: Chan, Xian Yang, et al.
Publicado: (2017)

Endothelial eNAMPT amplifies pre-clinical acute lung injury: efficacy of an eNAMPT-neutralising monoclonal antibody
por: Quijada, Hector, et al.
Publicado: (2021)

Recapitulation
Publicado: (1866)

Antitumor effect of combined NAMPT and CD73 inhibition in an ovarian cancer model
por: Sociali, Giovanna, et al.
Publicado: (2015)

Adult-onset CblC deficiency: a challenging diagnosis involving different adult clinical specialists
por: Kalantari, Silvia, et al.
Publicado: (2022)

Regulation of NAMPT in Human Gingival Fibroblasts and Biopsies
por: Damanaki, Anna, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_j7sk5rtbvrj4bqp53kqsehk4n9