The RASSF1A Tumor Suppressor Binds the RasGAP DAB2IP and Modulates RAS Activation in Lung Cancer

SIMPLE SUMMARY: The RASSF1A tumor suppressor can serve as a pro-apoptotic effector of the K-RAS oncoprotein. It is frequently inactivated epigenetically in lung cancer, and genetic inactivation of RASSF1A in transgenic mice enhances the ability of mutant K-RAS to promote tumorigenesis. Here we show...

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Detalles Bibliográficos
Autores principales: Harrell Stewart, Desmond R., Schmidt, M. Lee, Donninger, Howard, Clark, Geoffrey J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766191/
https://www.ncbi.nlm.nih.gov/pubmed/33348649
http://dx.doi.org/10.3390/cancers12123807

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766191/
https://www.ncbi.nlm.nih.gov/pubmed/33348649
http://dx.doi.org/10.3390/cancers12123807

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