Structure-Based Discovery and Bioactivity Evaluation of Novel Aurora-A Kinase Inhibitors as Anticancer Agents via Docking-Based Comparative Intermolecular Contacts Analysis (dbCICA)

Aurora-A kinase plays a central role in mitosis, where aberrant activation contributes to cancer by promoting cell cycle progression, genomic instability, epithelial-mesenchymal transition, and cancer stemness. Aurora-A kinase inhibitors have shown encouraging results in clinical trials but have not...

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Detalles Bibliográficos
Autores principales: Hijjawi, Majd S., Abutayeh, Reem Fawaz, Taha, Mutasem O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766225/
https://www.ncbi.nlm.nih.gov/pubmed/33353031
http://dx.doi.org/10.3390/molecules25246003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766225/
https://www.ncbi.nlm.nih.gov/pubmed/33353031
http://dx.doi.org/10.3390/molecules25246003

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