Phosphate Groups in the Lipid A Moiety Determine the Effects of LPS on Hepatic Stellate Cells: A Role for LPS-Dephosphorylating Activity in Liver Fibrosis

Alkaline phosphatase (AP) activity is highly upregulated in plasma during liver diseases. Previously, we demonstrated that AP is able to detoxify lipopolysaccharide (LPS) by dephosphorylating its lipid A moiety. Because a role of gut-derived LPS in liver fibrogenesis has become evident, we now exami...

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Detalles Bibliográficos
Autores principales: Schippers, Marlies, Post, Eduard, Eichhorn, Ilse, Langeland, Jitske, Beljaars, Leonie, Malo, Madhu S., Hodin, Richard A., Millán, José Luis, Popov, Yury, Schuppan, Detlef, Poelstra, Klaas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766276/
https://www.ncbi.nlm.nih.gov/pubmed/33348845
http://dx.doi.org/10.3390/cells9122708

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766276/
https://www.ncbi.nlm.nih.gov/pubmed/33348845
http://dx.doi.org/10.3390/cells9122708

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