Advanced Glycation End Product Inhibitor Pyridoxamine Attenuates IVD Degeneration in Type 2 Diabetic Rats

Type 2 diabetes mellitus (T2DM) is associated with advanced glycation end product (AGE) enrichment and considered a risk factor for intervertebral disc (IVD) degeneration. We hypothesized that systemic AGE inhibition, achieved using pyridoxamine (PM), attenuates IVD degeneration in T2DM rats. To ind...

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Detalles Bibliográficos
Autores principales: Glaeser, Juliane D., Ju, Derek, Tawackoli, Wafa, Yang, Jae H., Salehi, Khosrowdad, Stefanovic, Tina, Kanim, Linda E. A., Avalos, Pablo, Kaneda, Giselle, Stephan, Stephen, Metzger, Melodie F., Bae, Hyun W., Sheyn, Dmitriy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766438/
https://www.ncbi.nlm.nih.gov/pubmed/33352698
http://dx.doi.org/10.3390/ijms21249709

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766438/
https://www.ncbi.nlm.nih.gov/pubmed/33352698
http://dx.doi.org/10.3390/ijms21249709

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