Cerebrospinal Fluid Penetration and Combination Therapy of Entrectinib for Disseminated ROS1/NTRK-Fusion Positive Pediatric High-Grade Glioma

Targeting oncogenic fusion-genes in pediatric high-grade gliomas (pHGG) with entrectinib has emerged as a highly promising therapeutic approach. Despite ongoing clinical studies, to date, no reports on the treatment of cerebrospinal fluid (CSF) disseminated fusion-positive pHGG exist. Moreover, clin...

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Detalles Bibliográficos
Autores principales: Mayr, Lisa, Guntner, Armin S., Madlener, Sibylle, Schmook, Maria T., Peyrl, Andreas, Azizi, Amedeo A., Dieckmann, Karin, Reisinger, Dominik, Stepien, Natalia M., Schramm, Kathrin, Laemmerer, Anna, Jones, David T. W., Ecker, Jonas, Sahm, Felix, Milde, Till, Pajtler, Kristian W., Blattner-Johnson, Mirjam, Strbac, Miroslav, Dorfer, Christian, Czech, Thomas, Kirchhofer, Dominik, Gabler, Lisa, Berger, Walter, Haberler, Christine, Müllauer, Leonhard, Buchberger, Wolfgang, Slavc, Irene, Lötsch-Gojo, Daniela, Gojo, Johannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766483/
https://www.ncbi.nlm.nih.gov/pubmed/33353026
http://dx.doi.org/10.3390/jpm10040290

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766483/
https://www.ncbi.nlm.nih.gov/pubmed/33353026
http://dx.doi.org/10.3390/jpm10040290

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