The Effect of Deuteration on the H(2) Receptor Histamine Binding Profile: A Computational Insight into Modified Hydrogen Bonding Interactions

We used a range of computational techniques to reveal an increased histamine affinity for its H(2) receptor upon deuteration, which was interpreted through altered hydrogen bonding interactions within the receptor and the aqueous environment preceding the binding. Molecular docking identified the ar...

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Detalles Bibliográficos
Autores principales: Hok, Lucija, Mavri, Janez, Vianello, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766521/
https://www.ncbi.nlm.nih.gov/pubmed/33353215
http://dx.doi.org/10.3390/molecules25246017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766521/
https://www.ncbi.nlm.nih.gov/pubmed/33353215
http://dx.doi.org/10.3390/molecules25246017

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