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The Effect of Deuteration on the H(2) Receptor Histamine Binding Profile: A Computational Insight into Modified Hydrogen Bonding Interactions
We used a range of computational techniques to reveal an increased histamine affinity for its H(2) receptor upon deuteration, which was interpreted through altered hydrogen bonding interactions within the receptor and the aqueous environment preceding the binding. Molecular docking identified the ar...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766521/ https://www.ncbi.nlm.nih.gov/pubmed/33353215 http://dx.doi.org/10.3390/molecules25246017 |