Engineering an Effective Human SNAP-23 Cleaving Botulinum Neurotoxin A Variant

Botulinum neurotoxin (BoNT) serotype A inhibits neurotransmitter release by cleaving SNAP-25 and represents an established pharmaceutical for treating medical conditions caused by hyperactivity of cholinergic nerves. Oversecretion from non-neuronal cells is often also the cause of diseases. Notably,...

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Detalles Bibliográficos
Autores principales: Sikorra, Stefan, Donald, Sarah, Elliott, Mark, Schwede, Susan, Coker, Shu-Fen, Kupinski, Adam P., Tripathi, Vineeta, Foster, Keith, Beard, Matthew, Binz, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766560/
https://www.ncbi.nlm.nih.gov/pubmed/33352834
http://dx.doi.org/10.3390/toxins12120804

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766560/
https://www.ncbi.nlm.nih.gov/pubmed/33352834
http://dx.doi.org/10.3390/toxins12120804

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