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Nucleic Acid Delivery by Solid Lipid Nanoparticles Containing Switchable Lipids: Plasmid DNA vs. Messenger RNA

The development of safe and effective nucleic acid delivery systems remains a challenge, with solid lipid nanoparticle (SLN)-based vectors as one of the most studied systems. In this work, different SLNs were developed, by combination of cationic and ionizable lipids, for delivery of mRNA and pDNA....

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Detalles Bibliográficos
Autores principales: Gómez-Aguado, Itziar, Rodríguez-Castejón, Julen, Vicente-Pascual, Mónica, Rodríguez-Gascón, Alicia, del Pozo-Rodríguez, Ana, Solinís Aspiazu, María Ángeles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766580/
https://www.ncbi.nlm.nih.gov/pubmed/33352904
http://dx.doi.org/10.3390/molecules25245995