Cargando…

Nucleic Acid Delivery by Solid Lipid Nanoparticles Containing Switchable Lipids: Plasmid DNA vs. Messenger RNA

The development of safe and effective nucleic acid delivery systems remains a challenge, with solid lipid nanoparticle (SLN)-based vectors as one of the most studied systems. In this work, different SLNs were developed, by combination of cationic and ionizable lipids, for delivery of mRNA and pDNA....

Descripción completa

Detalles Bibliográficos
Autores principales:	Gómez-Aguado, Itziar, Rodríguez-Castejón, Julen, Vicente-Pascual, Mónica, Rodríguez-Gascón, Alicia, del Pozo-Rodríguez, Ana, Solinís Aspiazu, María Ángeles
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766580/ https://www.ncbi.nlm.nih.gov/pubmed/33352904 http://dx.doi.org/10.3390/molecules25245995

Ejemplares similares

Galactomannan-Decorated Lipidic Nanocarrier for Gene Supplementation Therapy in Fabry Disease
por: Rodríguez-Castejón, Julen, et al.
Publicado: (2022)

α-Galactosidase A Augmentation by Non-Viral Gene Therapy: Evaluation in Fabry Disease Mice
por: Rodríguez-Castejón, Julen, et al.
Publicado: (2021)

Topical Administration of SLN-Based Gene Therapy for the Treatment of Corneal Inflammation by De Novo IL-10 Production
por: Vicente-Pascual, Mónica, et al.
Publicado: (2020)

Nanomedicines to Deliver mRNA: State of the Art and Future Perspectives
por: Gómez-Aguado, Itziar, et al.
Publicado: (2020)

MMP-9 Downregulation with Lipid Nanoparticles for Inhibiting Corneal Neovascularization by Gene Silencing
por: Torrecilla, Josune, et al.
Publicado: (2019)

Development of nucleic acid vaccines: use of self-amplifying RNA in lipid nanoparticles
por: Rodríguez-Gascón, Alicia, et al.
Publicado: (2014)

Novel Golden Lipid Nanoparticles with Small Interference Ribonucleic Acid for Substrate Reduction Therapy in Fabry Disease
por: Beraza-Millor, Marina, et al.
Publicado: (2023)

mRNA-Based Nanomedicinal Products to Address Corneal Inflammation by Interleukin-10 Supplementation
por: Gómez-Aguado, Itziar, et al.
Publicado: (2021)

Lipid Nanoparticles as Carriers for RNAi against Viral Infections: Current Status and Future Perspectives
por: Torrecilla, Josune, et al.
Publicado: (2014)

Pharmacokinetic/Pharmacodynamic Analysis of Tedizolid Phosphate Compared to Linezolid for the Treatment of Infections Caused by Gram-Positive Bacteria
por: Rodríguez-Gascón, Alicia, et al.
Publicado: (2021)

The Role of PK/PD Analysis in the Development and Evaluation of Antimicrobials
por: Rodríguez-Gascón, Alicia, et al.
Publicado: (2021)

Multicomponent nanoparticles as nonviral vectors for the treatment of Fabry disease by gene therapy
por: Ruiz de Garibay, Aritz Pérez, et al.
Publicado: (2012)

Switchable Lipid Provides pH-Sensitive Properties to Lipid and Hybrid Polymer/Lipid Membranes
por: Passos Gibson, Victor, et al.
Publicado: (2020)

Pharmacokinetic/Pharmacodynamic Analysis of Oral Calcium Fosfomycin: Are Urine Levels Sufficient to Ensure Efficacy for Urinary Tract Infections?
por: Rodríguez-Gascón, Alicia, et al.
Publicado: (2023)

Oferta de servicios de atención farmacéutica: clave para un nuevo modelo de servicios de salud
por: Calvo Hernáez, Begoña, et al.
Publicado: (2022)

Encapsulation state of messenger RNA inside lipid nanoparticles
por: Brader, Mark L., et al.
Publicado: (2021)

The role of lipid second messengers in aldosterone synthesis and secretion
por: Spaulding, Shinjini C., et al.
Publicado: (2022)

Separation of Plasmid DNA Topological Forms, Messenger RNA, and Lipid Nanoparticle Aggregates Using an Ultrawide Pore Size Exclusion Chromatography Column
por: Goyon, Alexandre, et al.
Publicado: (2023)

Application of pharmacokinetic/pharmacodynamic analysis to evaluate the adequacy of antimicrobial therapy for pediatric acute otitis media in Spain before and after the introduction of the PCV7 vaccine
por: Ibar-Bariain, Maitane, et al.
Publicado: (2019)

A Click Cage: Organelle‐Specific Uncaging of Lipid Messengers
por: Wagner, Nicolai, et al.
Publicado: (2018)

Link between Lipid Second Messengers and Osmotic Stress in Plants
por: Rodas-Junco, Beatriz A., et al.
Publicado: (2021)

Imaging Endocannabinoids and Bioactive Lipid Messengers in Basic Research and Biomedical Application
por: Aoki, Jun, et al.
Publicado: (2022)

Delivery Systems of Plasmid DNA and Messenger RNA for Advanced Therapies
por: Uchida, Satoshi
Publicado: (2022)

Switchable CAR T cell strategy against osteosarcoma
por: Hidalgo, Laura, et al.
Publicado: (2023)

Effects of local structural transformation of lipid-like compounds on delivery of messenger RNA
por: Li, Bin, et al.
Publicado: (2016)

Treatment of Hemophilia A Using Factor VIII Messenger RNA Lipid Nanoparticles
por: Chen, Chun-Yu, et al.
Publicado: (2020)

Naturally Derived Membrane Lipids Impact Nanoparticle-Based Messenger RNA Delivery
por: Kim, Jeonghwan, et al.
Publicado: (2020)

Nucleic acid-lipid membrane interactions studied by DSC
por: Giatrellis, Sarantis, et al.
Publicado: (2011)

The roles of lipids and nucleic acids in HIV-1 assembly
por: Alfadhli, Ayna, et al.
Publicado: (2014)

Lipid Nanoparticles for Nucleic Acid Delivery to Endothelial Cells
por: Liu, Gary W., et al.
Publicado: (2023)

Phylogenomics of phosphoinositide lipid kinases: perspectives on the evolution of second messenger signaling and drug discovery
por: Brown, James R, et al.
Publicado: (2011)

Regulation of Ras Exchange Factors and Cellular Localization of Ras Activation by Lipid Messengers in T Cells
por: Jun, Jesse E., et al.
Publicado: (2013)

Continuous freeze-drying of messenger RNA lipid nanoparticles enables storage at higher temperatures
por: Meulewaeter, Sofie, et al.
Publicado: (2023)

Pseudomonas aeruginosa Susceptibility in Spain: Antimicrobial Activity and Resistance Suppression Evaluation by PK/PD Analysis
por: Valero, Ana, et al.
Publicado: (2021)

Quantification of Ceftaroline in Human Plasma Using High-Performance Liquid Chromatography with Ultraviolet Detection: Application to Pharmacokinetic Studies
por: Alarcia-Lacalle, Ana, et al.
Publicado: (2021)

Ionizable Lipid Nanoparticle-Mediated Delivery of Plasmid DNA in Cardiomyocytes
por: Scalzo, Sérgio, et al.
Publicado: (2022)

Lipid signaling to membrane proteins: From second messengers to membrane domains and adapter-free endocytosis
por: Hilgemann, Donald W., et al.
Publicado: (2018)

Cytosolic delivery of nucleic acids: The case of ionizable lipid nanoparticles
por: Schlich, Michele, et al.
Publicado: (2021)

Lipid Nanoparticle-Mediated Lymphatic Delivery of Immunostimulatory Nucleic Acids
por: Kim, Dongyoon, et al.
Publicado: (2021)

Structure and Function of Cationic and Ionizable Lipids for Nucleic Acid Delivery
por: Sun, Da, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_tlhamu24njba1uqmifjcg6q4jk