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Endothelial Protease Activated Receptor 1 (PAR1) Signalling Is Required for Lymphocyte Transmigration across Brain Microvascular Endothelial Cells

Lymphocyte transendothelial migration (TEM) relies on ICAM-1 engagement on the luminal surface of the endothelial cells (ECs). In blood–brain barrier (BBB) ECs, ICAM-1 triggers TEM signalling, including through JNK MAP kinase and AMP-activated protein kinase (AMPK), which lead to the phosphorylation...

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Detalles Bibliográficos
Autores principales:	Dragoni, Silvia, Papageorgiou, Anna, Araiz, Caroline, Greenwood, John, Turowski, Patric
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766634/ https://www.ncbi.nlm.nih.gov/pubmed/33371217 http://dx.doi.org/10.3390/cells9122723

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