Endothelial Protease Activated Receptor 1 (PAR1) Signalling Is Required for Lymphocyte Transmigration across Brain Microvascular Endothelial Cells

Lymphocyte transendothelial migration (TEM) relies on ICAM-1 engagement on the luminal surface of the endothelial cells (ECs). In blood–brain barrier (BBB) ECs, ICAM-1 triggers TEM signalling, including through JNK MAP kinase and AMP-activated protein kinase (AMPK), which lead to the phosphorylation...

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Detalles Bibliográficos
Autores principales: Dragoni, Silvia, Papageorgiou, Anna, Araiz, Caroline, Greenwood, John, Turowski, Patric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766634/
https://www.ncbi.nlm.nih.gov/pubmed/33371217
http://dx.doi.org/10.3390/cells9122723

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766634/
https://www.ncbi.nlm.nih.gov/pubmed/33371217
http://dx.doi.org/10.3390/cells9122723

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