Ouabain and Digoxin Activate the Proteasome and the Degradation of the ERα in Cells Modeling Primary and Metastatic Breast Cancer

SIMPLE SUMMARY: Breast cancer (BC) treatment relies on the detection of the estrogen receptor α (ERα). ERα-expressing BC patients are treated with anti-estrogen drugs (i.e., tamoxifen and fulvestrant). Despite their proven efficacy, these drugs cause serious side effects in a significant fraction of...

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Detalles Bibliográficos
Autores principales: Busonero, Claudia, Leone, Stefano, Bianchi, Fabrizio, Maspero, Elena, Fiocchetti, Marco, Palumbo, Orazio, Cipolletti, Manuela, Bartoloni, Stefania, Acconcia, Filippo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766733/
https://www.ncbi.nlm.nih.gov/pubmed/33352737
http://dx.doi.org/10.3390/cancers12123840

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766733/
https://www.ncbi.nlm.nih.gov/pubmed/33352737
http://dx.doi.org/10.3390/cancers12123840

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