Cargando…

Ouabain and Digoxin Activate the Proteasome and the Degradation of the ERα in Cells Modeling Primary and Metastatic Breast Cancer

SIMPLE SUMMARY: Breast cancer (BC) treatment relies on the detection of the estrogen receptor α (ERα). ERα-expressing BC patients are treated with anti-estrogen drugs (i.e., tamoxifen and fulvestrant). Despite their proven efficacy, these drugs cause serious side effects in a significant fraction of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Busonero, Claudia, Leone, Stefano, Bianchi, Fabrizio, Maspero, Elena, Fiocchetti, Marco, Palumbo, Orazio, Cipolletti, Manuela, Bartoloni, Stefania, Acconcia, Filippo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766733/ https://www.ncbi.nlm.nih.gov/pubmed/33352737 http://dx.doi.org/10.3390/cancers12123840

Ejemplares similares

A New Anti-Estrogen Discovery Platform Identifies FDA-Approved Imidazole Anti-Fungal Drugs as Bioactive Compounds against ERα Expressing Breast Cancer Cells
por: Cipolletti, Manuela, et al.
Publicado: (2021)

A functional genetic screen for metabolic proteins unveils GART and the de novo purine biosynthetic pathway as novel targets for the treatment of luminal A ERα expressing primary and metastatic invasive ductal carcinoma
por: Cipolletti, Manuela, et al.
Publicado: (2023)

The antiviral drug telaprevir induces cell death by reducing FOXA1 expression in estrogen receptor α (ERα)‐positive breast cancer cells
por: Bartoloni, Stefania, et al.
Publicado: (2022)

Clinically relevant CHK1 inhibitors abrogate wild-type and Y537S mutant ERα expression and proliferation in luminal primary and metastatic breast cancer cells
por: Pescatori, Sara, et al.
Publicado: (2022)

The Peculiar Estrogenicity of Diethyl Phthalate: Modulation of Estrogen Receptor α Activities in the Proliferation of Breast Cancer Cells
por: Fiocchetti, Marco, et al.
Publicado: (2021)

Dynamin II is required for 17β-estradiol signaling and autophagy-based ERα degradation
por: Totta, Pierangela, et al.
Publicado: (2016)

Beyond the Antioxidant Activity of Dietary Polyphenols in Cancer: the Modulation of Estrogen Receptors (ERs) Signaling
por: Cipolletti, Manuela, et al.
Publicado: (2018)

Unexpected Impact of a Hepatitis C Virus Inhibitor on 17β-Estradiol Signaling in Breast Cancer
por: Bartoloni, Stefania, et al.
Publicado: (2020)

Compensatory role of Neuroglobin in nervous and non-nervous cancer cells in response to the nutrient deprivation
por: Fiocchetti, Marco, et al.
Publicado: (2017)

Antiviral activity of digoxin and ouabain against SARS-CoV-2 infection and its implication for COVID-19
por: Cho, Junhyung, et al.
Publicado: (2020)

Cardiac Glycosides Ouabain and Digoxin Interfere with the Regulation of Glutamate Transporter GLAST in Astrocytes Cultured from Neonatal Rat Brain
por: Nguyen, Khoa T. D., et al.
Publicado: (2010)

Divergent Effects of Daidzein and Its Metabolites on Estrogen-Induced Survival of Breast Cancer Cells
por: Montalesi, Emiliano, et al.
Publicado: (2020)

Mechanism Underlying Naringenin Hypocholesterolemic Effects: Involvement of Estrogen Receptor α Subtype
por: Pallottini, Valentina, et al.
Publicado: (2022)

Ouabaïne
Publicado: (1891)

Neuroglobin in Breast Cancer Cells: Effect of Hypoxia and Oxidative Stress on Protein Level, Localization, and Anti-Apoptotic Function
por: Fiocchetti, Marco, et al.
Publicado: (2016)

Inappropriate use of digoxin in patients presenting with digoxin toxicity
por: Tatlisu, Mustafa Adem, et al.
Publicado: (2015)

Evaluation of the Sensitivity of Breast Cancer Cell Lines to Cardiac Glycosides Unveils ATP1B3 as a Possible Biomarker for the Personalized Treatment of ERα Expressing Breast Cancers
por: Acconcia, Filippo
Publicado: (2022)

Ammonium Activates Ouabain-Activated Signalling Pathway in Astrocytes: Therapeutic Potential of Ouabain Antagonist
por: Song, Dan, et al.
Publicado: (2014)

Use of digoxin-specific antibody fragments (Fab) in the management of digoxin poisoning.
por: Brown, J. H., et al.
Publicado: (1986)

A Novel Resveratrol-Induced Pathway Increases Neuron-Derived Cell Resilience against Oxidative Stress
por: Cracco, Patrizio, et al.
Publicado: (2023)

The ER retention protein RER1 promotes alpha-synuclein degradation via the proteasome
por: Park, Hyo-Jin, et al.
Publicado: (2017)

Neuroinflammation and Neutrophils: Modulation by Ouabain
por: Leite, Jacqueline Alves, et al.
Publicado: (2022)

Neuroglobin upregulation induced by 17β-estradiol sequesters cytocrome c in the mitochondria preventing H(2)O(2)-induced apoptosis of neuroblastoma cells
por: De Marinis, E, et al.
Publicado: (2013)

Xenoestrogens Alter Estrogen Receptor (ER) α Intracellular Levels
por: La Rosa, Piergiorgio, et al.
Publicado: (2014)

Digoxin Therapy of Fetal Superior Ventricular Tachycardia: Are Digoxin Serum Levels Reliable?
por: Saad, Antonio F., et al.
Publicado: (2016)

Chronic Digoxin Toxicity: An Evaluation of Digoxin-Specific Antibodies and Other Management Options
por: Clifford, Liam M, et al.
Publicado: (2023)

Neuroglobin: A New Possible Marker of Estrogen-Responsive Breast Cancer
por: Solar Fernandez, Virginia, et al.
Publicado: (2021)

Neuroglobin, a pro-survival player in estrogen receptor α-positive cancer cells
por: Fiocchetti, M, et al.
Publicado: (2014)

Resveratrol fuels HER2 and ERα-positive breast cancer behaving as proteasome inhibitor
por: Andreani, Cristina, et al.
Publicado: (2017)

Serum digoxin concentrations in dogs with atrial fibrillation under long term digoxin treatment
por: Colella, Antonella, et al.
Publicado: (2022)

Proteasome in action: substrate degradation by the 26S proteasome
por: Sahu, Indrajit, et al.
Publicado: (2021)

Ouabain binding to renal tubules of the rabbit
por: Shaver, J. L., et al.
Publicado: (1978)

Effect of ouabain on myocardial remodeling in rats
por: REN, YANPING, et al.
Publicado: (2013)

Nerol Attenuates Ouabain-Induced Arrhythmias
por: de Menezes-Filho, José Evaldo Rodrigues, et al.
Publicado: (2019)

Comment on ‘Quiescence and γH2AX in neuroblastoma are regulated by Ouabain/Na,K-ATPase': ouabain and cancer
por: Calderón-Montaño, J M, et al.
Publicado: (2013)

Neglected facts in digoxin intoxication
por: Serin, Sibel Ocak
Publicado: (2017)

‘Digoxin conundrum – Time for validation?’
por: Yadava, O.P.
Publicado: (2021)

A stalled retrotranslocation complex reveals physical linkage between substrate recognition and proteasomal degradation during ER-associated degradation
por: Nakatsukasa, Kunio, et al.
Publicado: (2013)

The proteasome and the degradation of oxidized proteins: Part II – protein oxidation and proteasomal degradation
por: Jung, Tobias, et al.
Publicado: (2013)

Reply: Comment on ‘Quiescence and yH2AX in neuroblastoma are regulated by ouabain/Na,K-ATPase': ouabain and cancer
por: Hiyoshi, H, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_c1dfmvm4h7v5fsfg3vait54nga