PARP Inhibition Increases the Reliance on ATR/CHK1 Checkpoint Signaling Leading to Synthetic Lethality—An Alternative Treatment Strategy for Epithelial Ovarian Cancer Cells Independent from HR Effectiveness

Poly (ADP-ribose) polymerase inhibitor (PARPi, olaparib) impairs the repair of DNA single-strand breaks (SSBs), resulting in double-strand breaks (DSBs) that cannot be repaired efficiently in homologous recombination repair (HRR)-deficient cancers such as BRCA1/2-mutant cancers, leading to synthetic...

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Detalles Bibliográficos
Autores principales: Gralewska, Patrycja, Gajek, Arkadiusz, Marczak, Agnieszka, Mikuła, Michał, Ostrowski, Jerzy, Śliwińska, Agnieszka, Rogalska, Aneta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766831/
https://www.ncbi.nlm.nih.gov/pubmed/33352723
http://dx.doi.org/10.3390/ijms21249715

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766831/
https://www.ncbi.nlm.nih.gov/pubmed/33352723
http://dx.doi.org/10.3390/ijms21249715

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