Activation of Soluble Polysaccharides with 1-Cyano-4-Dimethylaminopyridine Tetrafluoroborate (CDAP) for Use in Protein–Polysaccharide Conjugate Vaccines and Immunological Reagents. III Optimization of CDAP Activation

CDAP (1-cyano-4-dimethylaminopyridine tetrafluoroborate) is employed in the synthesis of conjugate vaccines as a cyanylating reagent. In the published method, which used pH 9 activation at 20 °C (Vaccine, 14:190, 1996), the rapid reaction made the process difficult to control. Here, we describe opti...

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Detalles Bibliográficos
Autores principales: Lees, Andrew, Barr, Jackson F., Gebretnsae, Samson
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766920/
https://www.ncbi.nlm.nih.gov/pubmed/33353255
http://dx.doi.org/10.3390/vaccines8040777

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766920/
https://www.ncbi.nlm.nih.gov/pubmed/33353255
http://dx.doi.org/10.3390/vaccines8040777

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