Kindlin-2 Mediates Mechanical Activation of Cardiac Myofibroblasts

We identify the focal adhesion protein kindlin-2 as player in a novel mechanotransduction pathway that controls profibrotic cardiac fibroblast to myofibroblast activation. Kindlin-2 is co-upregulated with the myofibroblast marker α-smooth muscle actin (α-SMA) in fibrotic rat hearts and in human card...

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Detalles Bibliográficos
Autores principales: Godbout, Elena, Son, Dong Ok, Hume, Stephanie, Boo, Stellar, Sarrazy, Vincent, Clément, Sophie, Kapus, Andras, Wehrle-Haller, Bernhard, Bruckner-Tuderman, Leena, Has, Cristina, Hinz, Boris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766948/
https://www.ncbi.nlm.nih.gov/pubmed/33348602
http://dx.doi.org/10.3390/cells9122702

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766948/
https://www.ncbi.nlm.nih.gov/pubmed/33348602
http://dx.doi.org/10.3390/cells9122702

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