BRCA Methylation Testing Identifies a Subset of Ovarian Carcinomas without Germline Variants That Can Benefit from PARP Inhibitor

Homologous Recombination Deficiency (HRD) is a frequent feature of high-grade epithelial ovarian carcinoma (EOC), associated with sensitivity to PARP-inhibitors (PARPi). The best characterized causes of HRD in EOCs are germline or somatic mutations in BRCA1 and BRCA2 genes. Although promoter methyla...

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Detalles Bibliográficos
Autores principales: Sahnane, Nora, Carnevali, Ileana, Formenti, Giorgio, Casarin, Jvan, Facchi, Sofia, Bombelli, Raffaella, Di Lauro, Eleonora, Memoli, Domenico, Salvati, Annamaria, Rizzo, Francesca, Sessa, Fausto, Tibiletti, Maria Grazia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767143/
https://www.ncbi.nlm.nih.gov/pubmed/33352687
http://dx.doi.org/10.3390/ijms21249708

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767143/
https://www.ncbi.nlm.nih.gov/pubmed/33352687
http://dx.doi.org/10.3390/ijms21249708

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