Development of HER2-Specific Aptamer-Drug Conjugate for Breast Cancer Therapy

In this study, HER2 RNA aptamers were conjugated to mertansine (DM1) and the anti-cancer effectiveness of the conjugate was evaluated in HER2-overexpressing breast cancer models. The conjugate of HER2 aptamer and anticancer drug DM1 (aptamer-drug conjugate, ApDC) was prepared and analyzed using HPLC...

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Detalles Bibliográficos
Autores principales: Jeong, Hwa Yeon, Kim, Hyeri, Lee, Myunghwa, Hong, Jinju, Lee, Joo Han, Kim, Jeonghyeon, Choi, Moon Jung, Park, Yong Serk, Kim, Sung-Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767363/
https://www.ncbi.nlm.nih.gov/pubmed/33371333
http://dx.doi.org/10.3390/ijms21249764

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767363/
https://www.ncbi.nlm.nih.gov/pubmed/33371333
http://dx.doi.org/10.3390/ijms21249764

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