Variations in BK Polyomavirus Immunodominant Large Tumor Antigen-Specific 9mer CD8 T-Cell Epitopes Predict Altered HLA-Presentation and Immune Failure

Failing BK polyomavirus (BKPyV)-specific immune control is underlying onset and duration of BKPyV-replication and disease. We focused on BKPyV-specific CD8 T-cells as key effectors and characterized immunodominant 9mer epitopes in the viral large tumor-antigen (LTag). We investigated the variation o...

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Detalles Bibliográficos
Autores principales: Leuzinger, Karoline, Kaur, Amandeep, Wilhelm, Maud, Hirsch, Hans H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767524/
https://www.ncbi.nlm.nih.gov/pubmed/33371492
http://dx.doi.org/10.3390/v12121476

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767524/
https://www.ncbi.nlm.nih.gov/pubmed/33371492
http://dx.doi.org/10.3390/v12121476

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