A Sextuple Knockout Cell Line System to Study the Differential Roles of CRY, PER, and NR1D in the Transcription-Translation Feedback Loop of the Circadian Clock

The transcription-translation feedback loop (TTFL) is the core mechanism of the circadian rhythm. In mammalian cells, CLOCK-BMAL1 proteins activate the downstream genes by binding on the E-box sequence of the clock-controlled genes. Among these gene products, CRY1, CRY2, PER1, PER2, NR1D1, and NR1D2...

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Detalles Bibliográficos
Autores principales: Chiou, Yi-Ying, Li, Tzu-Ying, Yang, Yanyan, Sancar, Aziz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768009/
https://www.ncbi.nlm.nih.gov/pubmed/33381013
http://dx.doi.org/10.3389/fnins.2020.616802

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768009/
https://www.ncbi.nlm.nih.gov/pubmed/33381013
http://dx.doi.org/10.3389/fnins.2020.616802

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