IMiDs induce FAM83F degradation via an interaction with CK1α to attenuate Wnt signalling

Immunomodulatory imide drugs (IMiDs) bind CRBN, a substrate receptor of the Cul4A E3 ligase complex, enabling the recruitment of neo-substrates, such as CK1α, and their degradation via the ubiquitinproteasome system. Here, we report FAM83F as such a neo-substrate. The eight FAM83 proteins (A-H) inte...

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Detalles Bibliográficos
Autores principales: Dunbar, Karen, Macartney, Thomas J, Sapkota, Gopal P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768194/
https://www.ncbi.nlm.nih.gov/pubmed/33361334
http://dx.doi.org/10.26508/lsa.202000804

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768194/
https://www.ncbi.nlm.nih.gov/pubmed/33361334
http://dx.doi.org/10.26508/lsa.202000804

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