A New Crystal Form of the SARS-CoV-2 Receptor Binding Domain: CR3022 Complex—An Ideal Target for In-Crystal Fragment Screening of the ACE2 Binding Site Surface

In-crystal fragment screening is a powerful tool to chemically probe the surfaces used by proteins to interact, and identify the chemical space worth exploring to design protein-protein inhibitors. A crucial prerequisite is the identification of a crystal form where the target area is exposed and ac...

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Detalles Bibliográficos
Autores principales: Nichols, Charlie, Ng, Joseph, Keshu, Annika, Fraternali, Franca, De Nicola, Gian F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768231/
https://www.ncbi.nlm.nih.gov/pubmed/33381049
http://dx.doi.org/10.3389/fphar.2020.615211

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768231/
https://www.ncbi.nlm.nih.gov/pubmed/33381049
http://dx.doi.org/10.3389/fphar.2020.615211

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