GSK3β Impairs KIF1A Transport in a Cellular Model of Alzheimer’s Disease but Does Not Regulate Motor Motility at S402

Impairment of axonal transport is an early pathologic event that precedes neurotoxicity in Alzheimer’s disease (AD). Soluble amyloid-β oligomers (AβOs), a causative agent of AD, activate intracellular signaling cascades that trigger phosphorylation of many target proteins, including tau, resulting i...

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Detalles Bibliográficos
Autores principales: Gan, K.J., Akram, A., Blasius, T.L., Ramser, E.M., Budaitis, B.G., Gabrych, D.R., Verhey, K.J., Silverman, M.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2020
Materias:
Research Article: Negative Results
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768277/
https://www.ncbi.nlm.nih.gov/pubmed/33067366
http://dx.doi.org/10.1523/ENEURO.0176-20.2020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768277/
https://www.ncbi.nlm.nih.gov/pubmed/33067366
http://dx.doi.org/10.1523/ENEURO.0176-20.2020

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