Crystal structure of the FERM-folded talin head reveals the determinants for integrin binding

Binding of the intracellular adapter proteins talin and its cofactor, kindlin, to the integrin receptors induces integrin activation and clustering. These processes are essential for cell adhesion, migration, and organ development. Although the talin head, the integrin-binding segment in talin, poss...

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Detalles Bibliográficos
Autores principales: Zhang, Pingfeng, Azizi, Latifeh, Kukkurainen, Sampo, Gao, Tong, Baikoghli, Mo, Jacquier, Marie-Claude, Sun, Yijuan, Määttä, Juha A. E., Cheng, R. Holland, Wehrle-Haller, Bernhard, Hytönen, Vesa P., Wu, Jinhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768682/
https://www.ncbi.nlm.nih.gov/pubmed/33288722
http://dx.doi.org/10.1073/pnas.2014583117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768682/
https://www.ncbi.nlm.nih.gov/pubmed/33288722
http://dx.doi.org/10.1073/pnas.2014583117

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