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Direct lysosome-based autophagy of lipid droplets in hepatocytes

Hepatocytes metabolize energy-rich cytoplasmic lipid droplets (LDs) in the lysosome-directed process of autophagy. An organelle-selective form of this process (macrolipophagy) results in the engulfment of LDs within double-membrane delimited structures (autophagosomes) before lysosomal fusion. Wheth...

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Detalles Bibliográficos
Autores principales: Schulze, Ryan J., Krueger, Eugene W., Weller, Shaun G., Johnson, Katherine M., Casey, Carol A., Schott, Micah B., McNiven, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768785/
https://www.ncbi.nlm.nih.gov/pubmed/33288726
http://dx.doi.org/10.1073/pnas.2011442117