Dual targeting of GSK3B and HDACs reduces tumor growth and improves survival in an ovarian cancer mouse model

OBJECTIVE. To investigate the anti-tumor effect of a newly-developed dual inhibitor (APCS-540) of glycogen synthase kinase 3 beta (GSK3B) and histone deacetylases (HDACs) in ovarian cancer cells. METHODS. The effects of APCS-540 on cancer cell proliferation, migration, invasion and cancer stemness w...

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Detalles Bibliográficos
Autores principales: Taylan, Enes, Zayou, Fouzia, Murali, Ramachandran, Karlan, Beth Y., Pandol, Stephen J., Edderkaoui, Mouad, Orsulic, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769125/
https://www.ncbi.nlm.nih.gov/pubmed/32698955
http://dx.doi.org/10.1016/j.ygyno.2020.07.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769125/
https://www.ncbi.nlm.nih.gov/pubmed/32698955
http://dx.doi.org/10.1016/j.ygyno.2020.07.005

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