Cargando…

An ATM–Chk2–INCENP pathway activates the abscission checkpoint

During cell division, in response to chromatin bridges, the chromosomal passenger complex (CPC) delays abscission to prevent chromosome breakage or tetraploidization. Here, we show that inhibition of ATM or Chk2 kinases impairs CPC localization to the midbody center, accelerates midbody resolution i...

Descripción completa

Detalles Bibliográficos
Autores principales: Petsalaki, Eleni, Zachos, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769160/
https://www.ncbi.nlm.nih.gov/pubmed/33355621
http://dx.doi.org/10.1083/jcb.202008029